Method validation using Certified Reference Materials (CRMs)

Introduction: why method validation matters

In today’s highly regulated scientific landscape, method validation is the bedrock of accurate and reproducible analytical results. Whether your laboratory operates in petrochemicals, pharmaceuticals, environmental testing, or food safety, validated methodologies ensure integrity, traceability, and compliance with international standards like ISO/IEC 17025 and regulatory guidelines.

Certified Reference Materials (CRMs) helps you in achieving reliable validation.

What is Method Validation?

Method validation is the process of proving that a given analytical method is suitable for its intended purpose. Regulatory and accreditation bodies require documented validation to confirm the reliability and reproducibility of test results.

Key parameters of method validation include:

  • Accuracy
  • Precision
  • Linearity

At every stage, CRMs play a crucial role in confirming and documenting method performance.

How Certified Reference Materials enhance method validation

✅ Accuracy

CRMs provide certified values, making them ideal for verifying the accuracy of your analytical methods. By comparing test results to certified values, laboratories can validate that they’re achieving acceptable results.

✅ Precision

Repeated use of the same CRM across multiple trials ensures precision by confirming consistent results with operators or instruments.

✅ Linearity

Using CRMs at varying concentrations helps construct reliable calibration curves, supporting linearity in quantitation and reducing analytical bias.

Real-World Applications

Certified reference materials are indispensable across a wide range of sectors and material properties, for example in Petroleum and Petrochemical Testing:

ARO Scientific specialise in supplying high-quality, ISO 17034 accredited CRMs that meet global standards for method validation and method verification Every CRM we manufacture is supported by comprehensive documentation, including:

  • Certificate of Analysis (CoA)
  • Traceability to SI Units
  • Stability and homogeneity testing

We offer custom formulations as well as a broad catalogue of standard reference materials, allowing you to validate every step of your testing process with confidence.

Strengthen your method validation with trusted CRMs

Whether you're launching a new testing protocol or re-validating an existing method, CRMs from ARO Scientific provide the traceability, precision, and compliance your laboratory demands.

Let ARO Scientific help you meet and exceed your validation standards.
Browse our complete range of Certified Reference Materials or contact us to discuss custom solutions for your lab.